Bcl-2(Rs956572) G/A Mutation in Cigarette Smokers and receptiveness to Lung Cancer

Cigarette smokingis the root cause of cancer and death from lung cancer. Singlenucleotidepolymorphisms(SNPs) are the salient location in an individual genome which influences the diseases. Since cigarette smoke contain large number of oxidants which may induce mutations. Bcl-2 SNPs have been found to be associated with predisposition of different cancers. In present study we examine the association of bcl-2 variant rs956572 with the cigarette smokers to predict the risk of smoking related cancers in smokers. Among the smokers, 42% were found with GG genotype, 43% were heterozygous GA and 15% were AA,respectively. Homozygous AA genotype was recorded (15%) more when compared to non-smokers (12%) whereas; heterozygous GA genotype was recorded (36%) less when compared to smokers (43%). There was a significant difference among GG, GA and AA genotypes with Chi–Square value = 6.05, p<0.05. However, GG vs GA and GG vs GA+AA genotype showed statistically significant with OR: 0.67 [0.48 – 0.96], p< 0.05 and the recessive model. Recent findings, suggest that bcl-2 G/A (rs956572) variation is associated with decreased expression of Bcl-2 proteins. Our finding gives a clue that the transition mutation of G/A (rs956572) may leads to the lung diseases including cancer in smokers. However, there will be a need of more extensive and elaborated study to establish bcl-2(rs956572) G/T as a prognostic marker for the risk of lung cancer in smokers.